The Pearson Lab
Neural Stem Cells – Development – Metabolism
Our Research
Our research focuses on neural stem cell biology. We aim to elucidate the intrinsic and extrinsic mechanisms that regulate neural stem cell fate. By determining how these regulatory mechanisms shape brain development, we hope to understand the basis of neurodevelopmental disorders such as epilepsy and Autism.
Current Projects
Determining the role of glucose metabolism and Glucose Transporter 1 during neural development
Modeling GLUT1 Deficiency Syndrome using human cerebral organoids
Elucidating the regulatory pathways of FOXP1 in neural stem cells and excitatory neurons
Our Lab Environment
We are based at Weill Cornell Medical College in the heart of the Upper East Side in New York City. We are part of the Center for Neurogenetics and Feil Family Brain and Mind Research Institute.
The Pearson Lab acknowledges that we stand on the land of the Lenape.
In the Pearson lab, we believe that science is for everyone.
We aim to provide enthusiastic scientists with opportunities and make science more diverse and inclusive.
We recognize that personal happiness should not depend on academic success.
We strive to maintain a healthy work-life balance.
Select Publications
2024
Foxp1 suppresses cortical angiogenesis and attenuates HIF-1alpha signaling to promote neural progenitor cell maintenance
https://www.embopress.org/doi/full/10.1038/s44319-024-00131-8
2023
Toward an understanding of glucose metabolism in radial glial biology and brain development
https://www.life-science-alliance.org/content/7/1/e202302193
2020
Foxp1 Regulates Neural Stem Cell Self-Renewal and
Bias Toward Deep Layer Cortical Fates
https://www.sciencedirect.com/science/article/pii/S2211124720300498
2022
TGFβ superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoids
https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(22)00422-
2017
Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection
2012
Foxp-Mediated Suppression of N-Cadherin Regulates Neuroepithelial Character and Progenitor Maintenance in the CNS
For full list of publications:
https://www.ncbi.nlm.nih.gov/myncbi/caroline.pearson.1/bibliography/public
Meet The Team
Caroline Alayne Pearson, PhD. Principal Investigator, Assistant Professor
Catherine Dyevich, BSc. Research Technician
Alexandra Rubin, Undergraduate Student
Want to join the team?1 Send your CV to cap4010@med.cornell.edu
Lab News
10/31/2024 Celebrating exciting new funding news at Abaita in midtown
Contact Us
cap4010@med.cornell.edu
Belfer Research Building
413 East 69th street
New York
NY 10065
USA
Funding
We greatly appreciate our funding sources, including:
- The American Epilepsy Society
- The Brain and Spine Research Institute at NYP/WCM
- The Glut1 Deficiency Foundation
- Mastercard Diversity Mentorship Collaborative at WCM
For more information about GLUT1 Deficiency Syndrome
For more information about FOXP1 Syndrome
- Weill Cornell Medicine is a comprehensive academic medical center that is committed to excellence in patient care, scientific discovery, and the education of future physicians and scientists in New York City and around the world. Our doctors and scientists – faculty from Weill Cornell Medical College, Weill Cornell Graduate School of Medical Sciences, and the Weill Cornell Physician Organization – are engaged in world-class clinical care and cutting-edge research that connect patients to the latest treatment innovations and prevention strategies. Located in the heart of the Upper East Side’s scientific corridor, Weill Cornell Medicine’s powerful network of collaborators extends to its parent university Cornell University; to Qatar, where an international campus offers a U.S. medical degree; and to programs in Tanzania, Haiti, Brazil, Austria, and Turkey. Our medical practices serve communities throughout New York City, and our faculty provide comprehensive care at New York-Presbyterian Hospital/Weill Cornell Medical Center, New York-Presbyterian/Lower Manhattan Hospital, New York-Presbyterian Hospital/Brooklyn Methodist Hospital, New York-Presbyterian Hospital/Westchester Behavioral Health Center, and New York-Presbyterian/Queens. At Weill Cornell Medicine, we work together to treat each individual, not just their conditions or illnesses, as we strive to deliver the finest possible care for our patients – the center of everything we do. Weill Cornell Medicine is an Equal Employment Opportunity Employer. Weill Cornell Medicine provides equal employment opportunities to all qualified applicants without regard to protected status, including race, sex, sexual orientation, gender identity, national origin, color, age, religion, protected veteran or disability status, or genetic information. ↩︎