The Pearson Lab
Neural Stem Cells – Development – Metabolism
Our Research
Our research focuses on neural stem cell biology. We aim to elucidate the intrinsic and extrinsic mechanisms that regulate neural stem cell fate. By determining how these regulatory mechanisms shape brain development, we hope to understand the basis of neurodevelopmental disorders such as epilepsy and Autism.
Current Projects
Determining the role of glucose metabolism and Glucose Transporter 1 during neural development
Modeling GLUT1 Deficiency Syndrome using human cerebral organoids
Elucidating the regulatory pathways of FOXP1 in neural stem cells and excitatory neurons
Our Lab Environment
We are based at Weill Cornell Medical College in the heart of the Upper East Side in New York City. We are part of the Center for Neurogenetics and Feil Family Brain and Mind Research Institute.
Select Publications
2024
Foxp1 suppresses cortical angiogenesis and attenuates HIF-1alpha signaling to promote neural progenitor cell maintenance
https://www.embopress.org/doi/full/10.1038/s44319-024-00131-8
2023
Toward an understanding of glucose metabolism in radial glial biology and brain development
https://www.life-science-alliance.org/content/7/1/e202302193
2020
Foxp1 Regulates Neural Stem Cell Self-Renewal and
Bias Toward Deep Layer Cortical Fates
https://www.sciencedirect.com/science/article/pii/S2211124720300498
2022
TGFβ superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoids
https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(22)00422-
2017
Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection
2012
Foxp-Mediated Suppression of N-Cadherin Regulates Neuroepithelial Character and Progenitor Maintenance in the CNS
For full list of publications:
https://www.ncbi.nlm.nih.gov/myncbi/caroline.pearson.1/bibliography/public
Meet The Team
Caroline Alayne Pearson, PhD.
Principal Investigator
Assistant Professor
Catherine Dyevich, BSc.
Research Technician
Alexandra Rubin
Undergraduate Student
Want to join the team?1 Send your CV to cap4010@med.cornell.edu
Lab News
3/28/2025
The Pearson labs first R01 grant has been approved for funding!
12/01/2024
The Pearson lab has received an R03 from NIH NIMH to continue our FOXP1 studies and elucidate the direct targets in neural progenitor cells and neurons
10/31/2024
Celebrating exciting new funding news at Abaita in midtown
Contact Us
cap4010@med.cornell.edu
Belfer Research Building
413 East 69th street
New York
NY 10065
USA
Funding
We greatly appreciate our funding sources, including:
- NIH NIMH
- NIH NINDS
- The American Epilepsy Society
- The Brain and Spine Research Institute at NYP/WCM
- The Glut1 Deficiency Foundation
- Mastercard Diversity Mentorship Collaborative at WCM
For more information about GLUT1 Deficiency Syndrome
For more information about FOXP1 Syndrome
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